Morpholine → 4-(2-Hydrazinyl-6-methyl-4-pyrimidinyl)morpholine

HRID 2074976Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2074976
Cl[C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.O.[NH2:17][NH2:18]>CO>[NH:17]([C:2]1[N:7]=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[C:4]([CH3:9])[N:3]=1)[NH2:18]

Komponenten

5

Edukt 3

HCID 8083MorpholineHCID 24654Hydrazine hydrate (1:1)HCID 794712,4-Dichloro-6-methylpyrimidine

Produkt 1

HCID 668584764-(2-Hydrazinyl-6-methyl-4-pyrimidinyl)morpholineAusbeute 59,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2,4-dichloro-6-methylpyrimidine (0.41 g, 2.50 mmol) in MeOH (5 mL) was added morpholine (0.5 mL, 5.73 mmol). The solution was stirred for 30 min at room temperature, and then hydrazine monohydrate (1.0 mL, 20.6 mmol) was added. The solution was then heated at 60° C. and stirred for 16 h. The solution was then cooled to room temperature and purified by reverse phase HPLC to afford 0.31 g of the title compound (59%) as a waxy white solid. MH+210.

Aufarbeitung

  1. temperatureThe solution was then heated at 60° C.
  2. stirringstirred for 16 h
  3. temperatureThe solution was then cooled to room temperature
  4. custompurified by reverse phase HPLC

Quellen und Nachweise

ORD-Eintrag
ord-da1608fe464742fc891b2316e834ad4b
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07919528B2

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