Hydroxyamine hydrochloride → 4-[3-(2-Amino-4-phenyl-quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

HRID 2075664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2075664
C(=[N:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]2[C:17](=[CH:18][C:19]([S:31][C:32]3[CH:33]=[C:34]([C:38]4([C:44]#[N:45])[CH2:43][CH2:42][O:41][CH2:40][CH2:39]4)[CH:35]=[CH:36][CH:37]=3)=[CH:20][CH:21]=2)[N:16]=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.NO.C([O-])(=O)C.[K+]>CO>[NH2:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:22]2[C:17](=[CH:18][C:19]([S:31][C:32]3[CH:33]=[C:34]([C:38]4([C:44]#[N:45])[CH2:39][CH2:40][O:41][CH2:42][CH2:43]4)[CH:35]=[CH:36][CH:37]=3)=[CH:20][CH:21]=2)[N:16]=1

Komponenten

5

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 517044Potassium AcetateHCID 866138274-{3-[2-(Benzhydrylidene-amino)-4-phenyl-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

Produkt 1

HCID 670910914-[3-(2-Amino-4-phenyl-quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1s (110 mg, 0.18 mmol), hydroxylamine hydrochloride (25 mg, 0.36 mmol), and potassium acetate (44 mg, 0.45 mmol) were dissolved in MeOH (10 mL) and stirred at room temperature for 30 minutes. The reaction was concentrated and diluted with EtOAc and water. The aqueous layer was extracted with EtOAc, and the combined organic layers were dried over MgSO4, filtered, and concentrated to give 1t.

Aufarbeitung

  1. concentrationThe reaction was concentrated
  2. additiondiluted with EtOAc and water
  3. extractionThe aqueous layer was extracted with EtOAc
  4. dry with materialthe combined organic layers were dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6326624228f1468b82dae49d1326d9be
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07919621B2

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