Oxalic Acid → (2R)-N-(piperidin-4-yl)oxolane-2-carboxamide

HRID 2079368Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2079368
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C@H:17]2[CH2:21][CH2:20][CH2:19][O:18]2)=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H].C(O)(=O)C(O)=O>C(O)C.C(O)(=O)C.[Pd].CC(O)C>[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C@H:17]2[CH2:21][CH2:20][CH2:19][O:18]2)=[O:16])[CH2:10][CH2:9]1

Komponenten

8

Edukt 3

HCID 971Oxalic AcidHCID 1246648(R)-tetrahydrofuran-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amideHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 28810902(2R)-N-(piperidin-4-yl)oxolane-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

(R)-Tetrahydro-furan-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide (128 g, 444 mmol) was dissolved in 300 mL ethanol and 50 mL acetic acid. Palladium on activated carbon (5 g) was added. A hydrogen pressure of 5 bars was applied, and hydrogenation was continued until no more hydrogen was consumed (about 5 days). The suspension was filtered through Celite, and the filtrate was evaporated to dryness under reduced pressure. The residue and oxalic acid (50 g, 555 mmol) were suspended in 500 mL 2-propanol and heated to dissolve the solids. Upon cooling, the oxalate salt of R-tetrahydro-furan-2-carboxylic acid piperidin-4-ylamide crystallized and was collected by filtration to yield (R)-Tetrahydro-furan-2-carboxylic acid piperidin-4-ylamide as an oxalate salt (99.0 g, 77%) as an off-white solid. 1H-NMR (300 MHz, DMSO-d6): δ 7.84 (d, J=7.8 Hz, 1H), 5.90 (bs, 2H), 4.18-4.14 (m, 1H), 3.89-3.67 (m, 3H), 3.25-3.20 (m, 2H), 2.94-2.71 (m, 2H), 2.13-2.00 (m, 1H), 1.56-1.58 (m, 6H) ppm.

Aufarbeitung

  1. customwas consumed (about 5 days)
  2. filtrationThe suspension was filtered through Celite
  3. customthe filtrate was evaporated to dryness under reduced pressure
  4. temperatureheated
  5. dissolutionto dissolve the solids
  6. temperatureUpon cooling
  7. customthe oxalate salt of R-tetrahydro-furan-2-carboxylic acid piperidin-4-ylamide crystallized
  8. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-0271cc4d19f4432b927f11a8134a68dc
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07928107B2

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