StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Diethyl Ether → HCID 54320917, Verbindung

HRID 2082118
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2082118
C1(=O)N(N([C:11](=[O:22])[CH2:12][S:13][C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)CC([O-])=O)C(=O)CC1.[NH2:25][C@@H:26]([C:28]([NH:30][CH2:31][C:32]([NH:34][CH2:35][C:36]([OH:38])=[O:37])=[O:33])=[O:29])[CH3:27].C(OCC)C>C(O)C.O>[C:14]([S:13][CH2:12][C:11]([NH:25][C@@H:26]([C:28]([NH:30][CH2:31][C:32]([NH:34][CH2:35][C:36]([OH:38])=[O:37])=[O:33])=[O:29])[CH3:27])=[O:22])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 3

HCID 3283Diethyl EtherHCID 1549427H-D-Ala-Gly-Gly-OHHCID 86743235HCID 86743235, Verbindung

Produkt 1

HCID 54320917HCID 54320917, VerbindungAusbeute 47 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittel
HCID 962
Water
Lösungsmittel

Versuchsvorschrift

To a solution of 1 g of succinimidyl-N-(S-benzoylmercaptoacetyl)glycinate in 25 ml of anhydrous ethanol at 70° C. is added in one portion a solution of 203 mg of D-alanylglycylglycine in 10 ml of water at 70° C. The reaction mixture is refluxed for 1 hour and the solvents are evaporated under reduced pressure. The residue is agitated with 5 portions of 25 ml acetone, which is isolated by filtration. The combined filtrates are treated with diethylether until precipitation is complete. The precipitate is filtered off, washed with diethylether and dried over P2O5 under vacuum to obtain 170 mg (47,7%) of S-benzoylmercaptoacetyl-D-alanylglycylglycine as a white powder, m.p. 167°-170° C.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for 1 hour
  2. customthe solvents are evaporated under reduced pressure
  3. customwhich is isolated by filtration
  4. filtrationThe precipitate is filtered off
  5. washwashed with diethylether
  6. dry with materialdried over P2O5 under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-7ddbbe26355542a9a5f6f2eb6e197a1e
Quelldatensatz
uspto-grants-1993_02
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05187264

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion