Diethyl Ether → 142348-17-2

HRID 2082130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2082130
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17]Br.C(=O)([O-])[O-].[Na+].[Na+].CCOCC>C(O)(C)C>[Br-:13].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][N+:10]2([CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:11][CH2:12]1

Komponenten

6

Edukt 4

HCID 3283Diethyl EtherHCID 80561,4-DibromobutaneHCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazine

Produkt 1

HCID 658423142348-17-2

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 40.8 g (0.25 mol) of 1-(2-pyridyl) piperazine (IV), 75.5 ml (134.9 g, 0.625 mol) of 1,4-dibromobutane (V) and 27.5 g (0.26 mol) of sodium carbonate was refluxed in 500 g of isopropyl alcohol for 16 hours, the hot mixture was filtered off from the salt precipitate, cooled, and the crystalline product was isolated. The additional amount of the product can be obtained by dilution of the mother liquor with a double volume of ether.

Aufarbeitung

  1. filtrationthe hot mixture was filtered off from the salt precipitate
  2. temperaturecooled
  3. customthe crystalline product was isolated

Quellen und Nachweise

ORD-Eintrag
ord-40188b3f3f644e2abd31b062beccdd31
Quelldatensatz
uspto-grants-1993_02
Patentnummer
US05187277

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