Acetic Acid → 3-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

HRID 2082876Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2082876
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5]O.C(O)(=O)C.[BrH:25]>C(OCC)C>[BrH:25].[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5][Br:25]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 536869293-Amino-2-benzyl-5-(hydroxymethyl)benzene-1-sulfonamide

Produkt 1

HCID 202945373-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

3-Amino-4-benzyl-5-sulfamylbenzyl alcohol (12.5 g; prepared as described in Example 4) is while stirring added in portions to acetic acid saturated with dry hydrogen bromide (60 ml), and the mixture is stirred for 24 hours. The resulting solution is diluted with diethyl ether (150 ml) and cooled to precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

Aufarbeitung

  1. stirringthe mixture is stirred for 24 hours
  2. temperaturecooled
  3. customto precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

Quellen und Nachweise

ORD-Eintrag
ord-1d863e0d0f6b49e69c8cf574965082b2
Quelldatensatz
uspto-grants-1978_04
Patentnummer
US04082851

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