Hydrochloric Acid → HCID 70166468, Verbindung

HRID 2083820Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2083820
CO.[ClH:3].[CH3:4][O:5][C:6](=[O:33])[C@H:7]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[NH:8][C:9](=[O:24])[C@H:10]([CH2:22][OH:23])[NH:11]C(OCC1C=CC=CC=1)=O.O>O1CCCC1.[Pd]>[ClH:3].[CH3:4][O:5][C:6](=[O:33])[C@H:7]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[NH:8][C:9](=[O:24])[C@H:10]([CH2:22][OH:23])[NH2:11]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 13190522Z-Ser-Tyr-OMe

Produkt 1

HCID 70166468HCID 70166468, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methanol (70 ml.) containing 6.67 ml. of 3N hydrogen chloride in tetrahydrofuran is added to a mixture of 8.328 g. of Nα -benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [cf. Fischer and Whetstone, J. Am. Chem. Soc., 76, 5076 (1954)] and 500 mg. of 20% palladium-on-carbon and the resulting mixture stirred under hydrogen at one inch water pressure for three hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated to dryness under reduced pressure to give a residue of L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-666658081b994ad580ca14b68fbb2b37
Quelldatensatz
uspto-grants-1978_04
Patentnummer
US04086219

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