Diethyl Ether → Ethyl 5-(morpholin-4-yl)pentanoate

HRID 2095185Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2095185
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.C(N(CC)CC)C.C(OCC)C>C(O)C>[N:11]1([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

Komponenten

6

Edukt 4

HCID 3283Diethyl EtherHCID 8083MorpholineHCID 8471TriethylamineHCID 84580Ethyl 5-bromovalerate

Produkt 1

HCID 16097789Ethyl 5-(morpholin-4-yl)pentanoateAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 5-bromovalerate (8 g, 38.3 mmole), morpholine (3.67 g, 42 mmole) and triethylamine (4.2 g, 42 mmole) in ethanol (100 mL) was heated to reflux overnight. The solution was concentrated to afford a gummy white solid which was mixed with diethyl ether and filtered to remove the solid. The filtrate was washed with saline (3×50 mL), dried over Na2SO4, filtered and concentrated in vacuo to afford 7.1 g (87%) of ethyl 5-morpholin-4-ylpentanoate as a pale brown liquid. MS (m/z, ES+): 217 (M+2, 100%), 216 (M+1, 57%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. concentrationThe solution was concentrated
  4. customto afford a gummy white solid which
  5. filtrationfiltered
  6. customto remove the solid
  7. washThe filtrate was washed with saline (3×50 mL)
  8. dry with materialdried over Na2SO4
  9. filtrationfiltered
  10. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4fc91f490fdc48c8a26d373c6d7a98eb
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08445694B2

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