Lithium hydroxide, monohydrate → 2,3-Dihydro-6-methoxy-3-oxo-1H-indene-5-carboxylic acid

HRID 2100750Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2100750
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH2:9][C:8]2=[O:16])=[O:4].O[Li].O>C1COCC1.O>[CH3:15][O:14][C:13]1[CH:12]=[C:11]2[C:7]([C:8](=[O:16])[CH2:9][CH2:10]2)=[CH:6][C:5]=1[C:3]([OH:4])=[O:2]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 57799525HCID 57799525, Verbindung

Produkt 1

HCID 537374072,3-Dihydro-6-methoxy-3-oxo-1H-indene-5-carboxylic acidAusbeute 90,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

6-Methoxy-3-oxo-indan-5-carboxylic acid methyl ester (4 g, 18.18 mmol) was added to a solution of LiOH.H2O (2.2 g, 54.5 mmol) in THF (40 ml) and H2O (40 ml), then the mixture was heated to reflux and stirred for one hour. After removal of THF, the residue was acidified to PH=3, and the precipitate was collected and dried to give a white solid (3.38 g, 89.8%). LC-MS: m/e 207 (MH+)

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto reflux
  3. customAfter removal of THF
  4. customthe precipitate was collected
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5dd27c492fec41a382126e7032e88c80
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07572809B2

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