Water → HCID 178507362, Verbindung

HRID 2102977

Reaktionsgleichung

Reaktionsgleichung von HRID 2102977
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[C:13](O)=[O:14])([O-])=O.[AlH4-].[Li+].O.[OH-].[Na+]>C1COCC1>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[CH2:13][OH:14]

Komponenten

6

Edukt 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 28112Lithium aluminum hydrideHCID 71446525-nitro-1H-indazole-3-carboxylic Acid

Produkt 1

HCID 178507362HCID 178507362, VerbindungAusbeute 19,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

5-nitro-1H-indazole-3-carboxylic acid (500 mg, 0.002 mol) was dissolved in 50 mL THF, added lithium tetrahydroaluminate (366 mg, 0.00964 mol) portionwise and stirred at room temperature overnight. 65 mg (15%). Water (366 μL), 15% NaOH solution (366 μL), and water (1.1 mL) were added cautiously and the mixtured was filtered. The filtrate was concentrated under vacuum to give the product (65 mg, 15%) as an oil. m/z=160.0.

Aufarbeitung

  1. filtrationthe mixtured was filtered
  2. concentrationThe filtrate was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-a40430eef0f64edfacf221c4acfceaea
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07576099B2

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