Methanol → 2-(3-Phenylureido)thiazole-4-carbaldehyde

HRID 2107236Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2107236
I([O-])(=O)(=O)=O.[Na+].[OH:7][CH:8]([C:11]1[N:12]=[C:13]([NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])[S:14][CH:15]=1)CO.CO>O>[C:20]1([NH:19][C:17](=[O:18])[NH:16][C:13]2[S:14][CH:15]=[C:11]([CH:8]=[O:7])[N:12]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 150535134-(1,2-Dihydroxyethyl)-2-(3-phenylureido)thiazoleHCID 23667635Sodium periodate

Produkt 1

HCID 150535142-(3-Phenylureido)thiazole-4-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 0.76 g of sodium metaperiodate in 15 ml of water was added dropwise at room temperature to a mixture comprising 0.5 g of 4-(1,2-dihydroxyethyl)-2-(3-phenylureido)thiazole and 15 ml of methanol, and the mixture was stirred for 2 hours after completion of the dropwise addition. The solvent was then evaporated off under reduced pressure and the residue was washed with water, giving the desired compound as a white powder.

Aufarbeitung

  1. additionafter completion of the dropwise addition
  2. customThe solvent was then evaporated off under reduced pressure
  3. washthe residue was washed with water

Quellen und Nachweise

ORD-Eintrag
ord-9904b6e62cfb41e9b34c048d856fe5f1
Quelldatensatz
uspto-grants-1990_06
Patentnummer
US04933355

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