Triethylamine → HCID 178473965, Verbindung

HRID 2109016Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2109016
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2].[I:15][C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19](O)=[O:20].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C>CN(C)C=O.O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:6](=[C:19]([OH:20])[C:18]2[CH:22]=[CH:23][CH:24]=[C:16]([I:15])[CH:17]=2)[C:5]1=[O:14])(=[O:3])[CH3:2]

Komponenten

7

Edukt 4

HCID 8471TriethylamineHCID 120603-Iodobenzoic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 116441611-Acetyl-6-chloroindolin-2-one

Produkt 1

HCID 178473965HCID 178473965, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

10.5 g 1-acetyl-6-chloro-2-indolinone (educt V.1), 13.6 g 3-iodobenzoic acid and 17.7 g TBTU are placed in 100 ml of dimethylformamide, 35 ml triethylamine are added and the mixture is stirred for 12 hours at ambient temperature. After this time the solvent is eliminated, the residue is combined with water, suction filtered and washed with a little water, methanol and ether and dried in vacuo at 100° C.

Aufarbeitung

  1. filtrationfiltered
  2. washwashed with a little water, methanol and ether
  3. customdried in vacuo at 100° C.

Quellen und Nachweise

ORD-Eintrag
ord-876d780ab8234cd5a96eb486e27c6a74
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07514468B2

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