1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 59811150, Verbindung

Dissolve 6-Amino-3′-trifluoromethyl-[2,2′]bipyridinyl-5-carboxylic acid hydrochloride (11.33 g, 35.44 mmol), N-hydroxy-succinimide (8.15 g, 70.9 mmol), and EDCI (10.19 g, 53.16 mmol) in a solution of dry THF (100 mL) and Hunig's base (16.12 g, 125 mmol). Stir the reaction mixture overnight at room temperature. Add ethyl acetate (200 mL) was and extract the organic phase with water (3×100 mL) and brine (100 mL). Dry the organic extract over Na2SO4 and remove the solvent under reduced pressure to yield the title compound as a brown foam.

1. extractionextract the organic phase with water (3×100 mL) and brine (100 mL)
2. customDry the
3. extractionorganic extract over Na2SO4
4. customremove the solvent under reduced pressure

ORD-Eintrag

ord-916ec148b1684f97b6de0038de356ff2

Quelldatensatz

uspto-grants-2008_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07432275B2