3-Pyridinemethanamine → 3-Chloro-4-phenyl-1-[(pyridin-3-yl)methyl]-1H-pyrrole-2,5-dione

HRID 2113741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2113741
[Cl:1][C:2]1[C:3](=[O:14])O[C:5](=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:15][CH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1>C(O)(=O)C>[Cl:1][C:2]1[C:3](=[O:14])[N:15]([CH2:16][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[C:5](=[O:13])[C:6]=1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Komponenten

4

Edukt 2

HCID 310183-PyridinemethanamineHCID 234471953-Chloro-4-phenylfuran-2,5-dione

Produkt 1

HCID 691451723-Chloro-4-phenyl-1-[(pyridin-3-yl)methyl]-1H-pyrrole-2,5-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 3-chloro-4-phenylfuran-2,5-dione (1.00 mmol, 209 mg) and 3-(aminomethyl)-pyridine (1.00 mmol, 26 mg) in glacial acetic acid (4 mL) was heated in a microwave reactor at 120° C. for two min. After cooling, the solvent was evaporated at reduced pressure. The crude product was used without purification.

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe solvent was evaporated at reduced pressure
  3. customThe crude product was used without purification

Quellen und Nachweise

ORD-Eintrag
ord-015f37b0aa2a452dbb71214733c18070
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07432288B2

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