Iodoethane → 1-Ethyl-7-fluoroindoline-2,3-dione

HRID 2114877Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2114877
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2=[O:12].I[CH2:14][CH3:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[CH2:14]([N:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[F:1])[C:7](=[O:12])[C:8]1=[O:11])[CH3:15]

Komponenten

6

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 5864187-Fluoroisatin

Produkt 1

HCID 692740961-Ethyl-7-fluoroindoline-2,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

7-Fluoro-1H-indole-2,3-dione (prepared according to the method of Gassman as described in U.S. Pat. No. 4,188,325 (4.00 g, 24.2 mmol), iodoethane (3.87 ml, 48.5 mmol) and potassium carbonate (6.61 g, 48.5 mmol) in DMF (20 ml) are stirred at room temperature for 20 hours. The reaction mixture is diluted with cold water and the resulting precipitate filtered and dried to give the title compound as an orange solid. HPLC r.t. 4.48 min; MS for C10H8FNO2 m/z 193.9 (M+H)+.

Aufarbeitung

  1. filtrationthe resulting precipitate filtered
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-48c4f2ed178347ee8f248cbbe5644e63
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07435751B2

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