Water → Tolterodine

HRID 2116871

Reaktionsgleichung

Reaktionsgleichung von HRID 2116871
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:7]=1.C(O)(C(O)=O)C(O)C(O)=O.O.C(=O)([O-])[O-].[Na+].[Na+].[OH-].[Na+]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:12]([CH3:14])[CH3:13])[CH:15]([CH3:16])[CH3:17])[CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 9847786(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate

Produkt 1

HCID 443879Tolterodine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Tolterodine tartrate (2.1 g) is mixed with water (45 ml) and toluene (2.5 ml). Sodium carbonate (800 mg) is added to the slurry. Sodium hydroxide (2.0 N, 1.5 ml) is added. The mixture is extracted three times with toluene (3 ml), saving the organic phase. Anhydrous potassium carbonate is added to the organic phase dissolve the tolterodine tartate, giving the title compound in solution.

Aufarbeitung

  1. extractionThe mixture is extracted three times with toluene (3 ml)
  2. additionAnhydrous potassium carbonate is added to the organic phase
  3. dissolutiondissolve the tolterodine tartate

Quellen und Nachweise

ORD-Eintrag
ord-00454ea3d27d4de6ae950ba71adb20fc
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07439397B2

Verknüpfte Notizen

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