Diethyl Ether → 1-Bromo-7-(prop-2-yn-1-yloxy)heptane

Temperatur

60 °C

25% (w/w) aq. NaOH (700 ml) was added to a stirred mixture of propargyl alcohol (70 g), tetra-butyl ammonium bromide (3.5 g) and 1,7-dibromoheptane (322 g) maintaining the temperature below 30° C. The reaction mixture was heated at 60° C. for 5 hrs then allowed to cool to room temperature and stirred overnight. Diethyl ether (350 ml) and water (280 ml) were added, the mixture stirred and allowed to settle. The aqueous layer was extracted with diethyl ether (210 ml), the organic layers combined, dried (MgSO4). The solution was concentrated to give 280 g of crude material. 140 g Of the crude was purified by chromatography on Biotage (800 g) eluting with petroleum ether then petroleum ether:ethyl acetate (100:1 followed by 100:1.5) to give the title compound (49.6 g).

1. temperaturemaintaining the temperature below 30° C
2. temperatureto cool to room temperature
3. stirringthe mixture stirred
4. extractionThe aqueous layer was extracted with diethyl ether (210 ml)
5. dry with materialdried (MgSO4)
6. concentrationThe solution was concentrated
7. customto give 280 g of crude material
8. custom140 g Of the crude was purified by chromatography on Biotage (800 g)
9. washeluting with petroleum ether

ORD-Eintrag

ord-e0913e33394e4054831f8898cba53acb

Quelldatensatz

uspto-grants-2008_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07442836B2