7-Amino-4-vinylisoindolinone → 7-Amino-4-ethylisoindolinone

HRID 21187

Reaktionsgleichung

Reaktionsgleichung von HRID 21187
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.[H][H]>CN(C=O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][CH3:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2

Komponenten

5

Edukt 2

HCID 684886597-Amino-4-vinylisoindolinoneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 684909697-Amino-4-ethylisoindolinoneAusbeute 102,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

7-Amino-4-vinylisoindolinone (50.0 mg, 0.287 mmol) was dissolved in DMF (2.5 mL), and the solution was added with 10% Pd—C (10 mg) followed by stirring at room temperature for 1.8 hours under normal pressure and hydrogen atmosphere. The reaction mixture was filtered using Celite and the solvent of the filtrate was evaporated under reduced pressure to obtain 7-amino-4-ethylisoindolinone (52.0 mg, quantitative).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9b574fe409a9418d963834a7bf341de1
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745641B2

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