Water → 2,3-Dihydro-6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid

HRID 21577Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 21577
[OH:1][C:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:14][CH3:15])[C:5]2[CH:6]=[CH:7][O:8][C:4]=2[C:3]=1[O:16][CH3:17].O.[OH-].[Na+].[H][H]>C(O)C.[Pd]>[OH:1][C:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:14][CH3:15])[C:5]2[CH2:6][CH2:7][O:8][C:4]=2[C:3]=1[O:16][CH3:17]

Komponenten

7

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 122114615-Benzofurancarboxylic acid, 6-hydroxy-4,7-dimethoxy-HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 199332212,3-Dihydro-6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acidAusbeute 73,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

5 g of 6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid in 75 ml of ethanol/25 ml of H2O/0.8 g of NaOH are hydrogenated in the presence of 1 g of Pd/C (10%) under atmospheric pressure and at 50° C. until uptake of hydrogen is complete. The mixture is filtered, the ethanol is removed by distillation, the aqueous phase is acidified, and the solid is filtered off with suction. 3.7 g of product are obtained and reacted further without purification.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. customthe ethanol is removed by distillation
  3. filtrationthe solid is filtered off with suction

Quellen und Nachweise

ORD-Eintrag
ord-d4e611dc44724a6b8160f1cb54fb0f2f
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05424330

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