[C:1]([NH:4][C:5]1[N:6]=[CH:7][S:8][CH:9]=1)(=[O:3])[CH3:2].[C:10]([O-])(=[O:12])[CH3:11].[Na+].C(Cl)(Cl)Cl>C(OC(=O)C)(=O)C.N1C=CC=CC=1>[C:1]([N:4]([C:10](=[O:12])[CH3:11])[C:5]1[N:6]=[CH:7][S:8][CH:9]=1)(=[O:3])[CH3:2]A solution of 4-acetylaminothiazole (2.85g, 20mM) in a mixture of acetic anhydride (30ml) and pyridine (10 ml) was heated at 100° C. for 16 hours. The reaction mixture was cooled and poured onto an ice cold mixture of 20% aqueous sodium acetate (200ml) and chloroform (200 ml.). The layers were separated the organic layer was washed with water, dried (MgSO4) and the solvents removed under vacuum to give an oil. Trituration with hexane followed by recrystallisation from di-isopropyl ether gave the title compound (1.8g, 49%) m.p. 55° C. (Found: C, 45.8; H, 4.4; N, 15.5%. C7H8N2O2S requires: C, 45.6; H, 4.4; N, 15.2%)
Wird geladen…
