Hydrochloric Acid → 2-(Phenethylhydrazono)-propionic acid

HRID 2163684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2163684
[CH2:1]([NH:9][N:10]=[C:11]([CH3:17])[C:12]([O:14]CC)=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH-].[K+].C(O)C.Cl>C(OCC)C.O>[CH2:1]([NH:9][N:10]=[C:11]([CH3:17])[C:12]([OH:14])=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 73183671Ethyl 2-(phenethylhydrazono)-propionate

Produkt 1

HCID 1942362-(Phenethylhydrazono)-propionic acidAusbeute 47 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

6 g. Ethyl 2-(phenethylhydrazono)-propionate (prepared according to Example 2) are dissolved in a solution of 1.4 g. potassium hydroxide in 28 ml. 80% ethanol and saponified at ambient temperature. After stirring for 30 hours, the reaction mixture is mixed with 25 ml. water and shaken out twice with 50 ml. amounts of diethyl ether. The aqueous phase is acidified with dilute hydrochloric acid. The crystals which precipitate out are filtered off and recrystallized from toluene. There is obtained 2-(phenethylhydrazono)-propionic acid in a yield of 47% of theory; m.p. 74°-76° C.

Aufarbeitung

  1. customsaponified at ambient temperature
  2. additionthe reaction mixture is mixed with 25 ml
  3. customThe crystals which precipitate out
  4. filtrationare filtered off
  5. customrecrystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-5d37c66fcbf04311a25a4636bf89f1cc
Quelldatensatz
uspto-grants-1979_01
Patentnummer
US04136196

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