Phenyl isocyanate → HCID 13469596, Verbindung

HRID 2164781

Reaktionsgleichung

Reaktionsgleichung von HRID 2164781
[SH:1][CH2:2][CH:3]([CH3:16])[C:4]([N:6]([CH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[CH2:7][C:8]([OH:10])=[O:9])=[O:5].[C:17]1([N:23]=[C:24]=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)Cl.CCOCC>[C:17]1([NH:23][C:24]([S:1][CH2:2][CH:3]([CH3:16])[C:4]([N:6]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:7][C:8]([OH:10])=[O:9])=[O:5])=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

5

Edukt 2

HCID 7672Phenyl isocyanateHCID 13469595(S)-[Cyclopentyl-(3-mercapto-2-methyl-propionyl)-amino]-acetic acid

Produkt 1

HCID 13469596HCID 13469596, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 4.9 g (0.02M) of N-(3-mercapto-2-methyl propanoyl)-N-cyclopentyl glycine and 8 ml of phenyl isocyanate in 5 ml methylene chloride was stirred at room temperature for 72 hours. The mixture was diluted with ether and filtered. The ether solution was washed with water, dried over MgSO4 and evaporated to dryness. The crude residue was dissolved in acetonitrile, treated with charcoal and crystallized by addition of ether, m.p. 170°-172° C.

Aufarbeitung

  1. filtrationfiltered
  2. washThe ether solution was washed with water
  3. dry with materialdried over MgSO4
  4. customevaporated to dryness
  5. dissolutionThe crude residue was dissolved in acetonitrile
  6. additiontreated with charcoal
  7. customcrystallized by addition of ether, m.p. 170°-172° C.

Quellen und Nachweise

ORD-Eintrag
ord-3ac4fe4686914f99bcccb03a55a98552
Quelldatensatz
uspto-grants-1985_03
Patentnummer
US04507316

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