StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Dimethylformamide → HCID 14370897, Verbindung

HRID 2165334
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2165334
CN([CH:4]=[O:5])C.[CH2:6]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([OH:28])=[O:27])=[CH:21][CH:20]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].Br[CH:30]([CH3:34])[C:31](O)=[O:32].[C:35](=O)([O-])[O-].[K+].[K+]>O>[CH2:6]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([O:28][CH:30]([C:31]([O:5][CH2:4][CH3:35])=[O:32])[CH3:34])=[O:27])=[CH:21][CH:20]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 117292-Bromopropionic acidHCID 10336152Benzeneacetic acid, 4-(dodecyloxy)-

Produkt 1

HCID 14370897HCID 14370897, VerbindungAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962
Water
Lösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a DMF solution (30 ml) of 4-dodecyloxyphenylacetic acid (2.4 g, 7.5 mmol.) and 2-bromopropionic acid (1.5 g, 8 mmol.) was added potassium carbonate (1.5 g, 10 mmol.). The mixture was stirred at 80° C. for 2 hours. The reaction solution was cooled, to which was added water (50 ml). The mixture was subjected to extraction with IPE. The organic layer was washed with water, dried and concentrated under reduced pressure. The concentrate was purified by means of a silica gel chromatography (developing solvent: IPE) to give 1-ethoxycarbonylethyl 4-dodecyloxyphenylacetate (2-i, 2.4 g, 76%).

Aufarbeitung

  1. temperatureThe reaction solution was cooled, to which
  2. extractionThe mixture was subjected to extraction with IPE
  3. washThe organic layer was washed with water
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe concentrate was purified by means of a silica gel chromatography (developing solvent: IPE)

Quellen und Nachweise

ORD-Eintrag
ord-e91a960c508948bd8dff69722ce7e319
Quelldatensatz
uspto-grants-1990_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04939274

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion