Bromine → HCID 90185062, Verbindung

HRID 2167697Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2167697
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:13])[C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.[Br:16]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:16][CH2:11][C:10](=[O:12])[C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:14])([F:15])[F:1])=[CH:8][CH:7]=1)=[O:13]

Komponenten

5

Edukt 3

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 27776811-[4-(trifluoromethyl)phenyl]propane-1,2-dione

Produkt 1

HCID 90185062HCID 90185062, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a chloroform (6.0 mL) solution of 1-[4-(trifluoromethyl)phenyl]propane-1,2-dione (0.65 g), bromine (0.62 mL) was added, and the resultant was stirred at 70° C. for 6 hours. After standing to cool to room temperature, a 10% aqueous sodium thiosulfate solution was added thereto, followed by extraction with chloroform. An organic layer was separated using a phase separator, and the solvent was distilled off under reduced pressure to obtain the title compound (1.1 g) as a yellow oil.

Aufarbeitung

  1. temperatureto cool to room temperature
  2. extractionfollowed by extraction with chloroform
  3. customAn organic layer was separated
  4. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ddd1b302b77b4f358ebda7331f22eccf
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09045466B2

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