Butyryl chloride → HCID 71279602, Verbindung

HRID 2171025Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2171025
[NH2:1][CH2:2][C:3]1([CH2:6][O:7][C:8]2[C:13]([O:14][CH3:15])=[C:12]([O:16][CH3:17])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[CH2:5][CH2:4]1.C(N(C(C)C)CC)(C)C.[C:37](Cl)(=[O:41])[CH2:38][CH2:39][CH3:40]>ClCCl>[CH3:15][O:14][C:13]1[C:12]([O:16][CH3:17])=[CH:11][CH:10]=[C:9]([C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[C:8]=1[O:7][CH2:6][C:3]1([CH2:2][NH:1][C:37](=[O:41])[CH2:38][CH2:39][CH3:40])[CH2:4][CH2:5]1

Komponenten

5

Edukt 3

HCID 8855Butyryl chlorideHCID 81531DiisopropylethylamineHCID 71279377HCID 71279377, Verbindung2×

Produkt 1

HCID 71279602HCID 71279602, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirring solution of 4-[2-(1-Aminomethyl-cyclopropylmethoxy)-3,4-dimethoxy-phenyl]-indan-1-one (Compound 182) (100 mg, 0.272 mmol) in dichloromethane (10 mL), were added diisopropylethylamine (0.034 g, 0.272 mmol) and butyryl chloride (29 mg, 0.272 mmol) and the resultant reaction mixture was subjected to the conditions used in the preparation of compound 183 to afford the title compound as a solid.

Aufarbeitung

  1. customthe resultant reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-43893b578d1e44e2b78058e9986427ff
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051290B2

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