Ethyl Acetate → HCID 59312979, Verbindung

HRID 2171477Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2171477
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[N:3]=1.[C:19]([NH:26][CH2:27][CH2:28][NH2:29])([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].C(N(C(C)C)CC)(C)C.C(OCC)(=O)C>CS(C)=O.O>[Cl:18][C:12]1[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=1[C:4]1[N:3]=[C:2]([NH:29][CH2:28][CH2:27][NH:26][C:19](=[O:20])[O:21][C:22]([CH3:24])([CH3:23])[CH3:25])[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=1

Komponenten

7

Edukt 4

HCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 59312932HCID 59312932, Verbindung

Produkt 1

HCID 59312979HCID 59312979, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

3.0 g (10.05 mmol) of 5-chloro-7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidine, 2.41 g (15.07 mmol) of N-Boc-ethylenediamine and 3.89 g (30.15 mmol) of diisopropylethylamine are dissolved in 50 ml of DMSO and heated at 120° C. for 16 h. Ethyl acetate and water are added, and the removed organic phase is washed twice more with water. The organic phase is dried with magnesium sulphate. Removal of the solvent results in 4.49 g (99% of theory) of product.

Aufarbeitung

  1. washthe removed organic phase is washed twice more with water
  2. dry with materialThe organic phase is dried with magnesium sulphate
  3. customRemoval of the solvent
  4. customresults in 4.49 g (99% of theory) of product

Quellen und Nachweise

ORD-Eintrag
ord-41aff043be4f40a58c41423154cdd8e8
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051323B2

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