Water → 6-({2-[(7-Chloroimidazo[1,2-c]pyrimidin-5-yl)amino]ethyl}amino)nicotinonitrile

HRID 2171484Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2171484
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[C:4]([Cl:11])[N:3]=1.FC(F)(F)C(O)=O.[NH2:19][CH2:20][CH2:21][NH:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][N:24]=1.CCN(C(C)C)C(C)C.O>CC(O)C>[Cl:11][C:4]1[N:3]=[C:2]([NH:19][CH2:20][CH2:21][NH:22][C:23]2[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][N:24]=2)[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 469421175,7-Dichloroimidazo[1,2-c]pyrimidineHCID 687096656-[(2-Aminoethyl)amino]nicotinonitrile trifluoroacetate

Produkt 1

HCID 593130766-({2-[(7-Chloroimidazo[1,2-c]pyrimidin-5-yl)amino]ethyl}amino)nicotinonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

707 mg (3.20 mmol) of 5,7-dichloroimidazo[1,2-c]pyrimidine (Example 11A) are suspended in 25 ml of 2-propanol, and 1.35 g (3.52 mmol) of 6-[(2-aminoethyl)amino]nicotinonitrile trifluoroacetate (Example 13A) and 1.03 g (7.99 mmol) of DIPEA are added. The mixture is heated at 80° C. for 16 h. After this time, water is added and the precipitate which has separated out is filtered off with suction. It is washed with a little 2-propanol/water and the resulting solid is dried under high vacuum. 523 mg (50% of theory) of the product are obtained.

Aufarbeitung

  1. customthe precipitate which has separated out
  2. filtrationis filtered off with suction
  3. washIt is washed with a little 2-propanol/water
  4. customthe resulting solid is dried under high vacuum
  5. custom523 mg (50% of theory) of the product are obtained

Quellen und Nachweise

ORD-Eintrag
ord-806e3e02aefc45049ad4e3939940781e
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051323B2

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