Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide

HRID 2172076

Reaktionsgleichung

Reaktionsgleichung von HRID 2172076
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>C(O)(=O)C>[BrH:1].[NH2:3][C:4]1[N:5]=[CH:6][C:7]([Br:1])=[CH:8][C:9]=1[CH:10]=[O:11]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 7376333-Pyridinecarboxaldehyde, 2-amino-

Produkt 1

HCID 866061462-Amino-5-bromonicotinaldehyde hydrobromideAusbeute 165,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

A solution of bromine (1.05 mL, 20.0 mmol) in acetic acid (20 mL) was added to a solution of 2-amino-3-pyridinecarboxaldehyde (2.5 g, 20 mmol) in acetic acid (50 mL) at room temperature. The reaction mixture was then stirred overnight. The resulting precipitate was filtered and washed with diethyl ether to give the title compound as a white solid (4.66 g, 80%).

Aufarbeitung

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-004bfe9f392342fab47f97a990d27bd0
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051321B2

Verknüpfte Notizen

Wird geladen…