N,N-dimethylhydroxylamine hydrochloride → 6-(3-ethylureido)-N-methoxy-N-methyl-4-(phenylamino)nicotinamide

HRID 2174242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2174242
[NH:1]([C:8]1[CH:13]=[C:12]([NH:14][C:15](=[O:19])[NH:16][CH2:17][CH3:18])[N:11]=[CH:10][C:9]=1[C:20]([OH:22])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:24][N:25](C)[OH:26].ON1C2C=CC=C[C:32]=2N=N1.Cl.C(N=C=NCCCN(C)C)C>CN(C)C1C=CN=CC=1.CN(C=O)C>[CH2:17]([NH:16][C:15](=[O:19])[NH:14][C:12]1[CH:13]=[C:8]([NH:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9]([C:20]([N:25]([O:26][CH3:32])[CH3:24])=[O:22])=[CH:10][N:11]=1)[CH3:18]

Komponenten

7

Edukt 4

HCID 27969N,N-dimethylhydroxylamine hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 896500056-(3-Ethylureido)-4-(phenylamino)nicotinic acid

Produkt 1

HCID 896503736-(3-ethylureido)-N-methoxy-N-methyl-4-(phenylamino)nicotinamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-anilino-6-(ethylcarbamoylamino)pyridine-3-carboxylic acid (i) (200 mg, 0.67 mmol), dimethylhydroxylamine hydrochloride (65 mg, 0.67 mmol), 4-dimethylaminopyridine (81 mg, 0.67 mmol) and N-hydroxybenzotriazole (90 mg, 0.67 mmol) were added to a dry RBF which was flushed with N2. DMF (1.5 mL) was added and the mixture stirred. 3-(ethyliminomethyleneamino)-N,N-dimethyl-propan-1-amine hydrochloride (150 mg, 0.80 mmol) was dissolved in DMF (1.5 mL) in a separate vial and this solution added to the reaction mixture at RT. The mixture was stirred overnight at RT.

Aufarbeitung

  1. customwas flushed with N2
  2. additionDMF (1.5 mL) was added
  3. additionadded to the reaction mixture at RT
  4. stirringThe mixture was stirred overnight at RT

Quellen und Nachweise

ORD-Eintrag
ord-822713183a2941bea96d1c37d5b8cf4d
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09060515B2

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