Hydrochloric Acid → 16-Cyanohexadecanoic acid

Temperatur

120 °C

A mixture of 16-bromohexadecanoic acid (16.61 g, 49.5 mmol), DMSO (150 ml), NaCN (12.5 g, 255 mmol), and NaI (1.92 g, 12.8 mmol) was stirred at 120° C. for 20 h. The mixture was allowed to cool to room temperature, and was then poured into a stirred mixture of water (1.7 l) and concentrated HCl (30 ml). Rinsing with water (100 ml). The resulting suspension was stirred at room temperature overnight. The product was filtered and washed with water (2×100 ml), and the solid was recrystallized twice from MeCN (90 ml and 50 ml). 10.1 g (72%) of 16-cyanohexadecanoic acid was obtained.

1. temperatureto cool to room temperature
2. washRinsing with water (100 ml)
3. stirringThe resulting suspension was stirred at room temperature overnight
4. filtrationThe product was filtered
5. washwashed with water (2×100 ml)
6. customthe solid was recrystallized twice from MeCN (90 ml and 50 ml)

ORD-Eintrag

ord-f433f1ecae224476a8e1681951906a1e

Quelldatensatz

uspto-grants-2015_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09061067B2