[OH-].[Li+].[C:3]1([S:9]([CH2:12][C:13]2[C:18]([C:19]([O:21]CC)=[O:20])=[C:17]([O:24][CH3:25])[C:16]([CH2:26][CH2:27][CH3:28])=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(O)=O>O1CCOCC1>[C:3]1([S:9]([CH2:12][C:13]2[C:18]([C:19]([OH:21])=[O:20])=[C:17]([O:24][CH3:25])[C:16]([CH2:26][CH2:27][CH3:28])=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1Lithium hydroxide (1M aqueous solution, 0.45 ml) was added to a solution of ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-propylbenzoate (Intermediate 24, 0.034 g) in dioxane and the solution was stirred and heated in the microwave at 160° C. for 15 minutes. The cooled solution was acidified by addition of formic acid and then purified by preparative HPLC (C18) eluting with a mixture of methanol and water containing 0.1% formic acid to give 6-(benzenesulphonylmethyl)-2-methoxy-3-propylbenzoic acid (0.024 g) as a white solid.
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