Formic Acid → 588702-95-8

HRID 2181656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2181656
C([O:3][CH:4](OCC)[C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)C.C(O)=O>O>[CH:4]([C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)=[O:3]

Komponenten

4

Edukt 2

HCID 284Formic AcidHCID 22481729HCID 22481729, Verbindung

Produkt 1

HCID 22481722588702-95-8Ausbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

Methyl 2-(diethoxymethyl)-1-benzofuran-6-carboxylate (2.71 g, 9.7 mmol) is treated drop-wise with formic acid (20 ml, 530 mmol) and water (5.5 ml). The reaction is stirred overnight at RT, diluted with water (50 ml), and the brown slurry is filtered. The cake is dried overnight to afford 1.86 g (94%) of methyl 2-formyl-1-benzofuran-6-carboxylate as an amber solid. 1H NMR (400 MHz, DMSO-d6): δ 3.91, 8.03, 8.28, 9.92 ppm.

Aufarbeitung

  1. filtrationthe brown slurry is filtered
  2. customThe cake is dried overnight

Quellen und Nachweise

ORD-Eintrag
ord-4dad4694ab0d4afaaea41f686a14aabe
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06894042B2

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