Ethanolamine → HCID 24012324, Verbindung

HRID 218279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 218279
[CH2:1]([NH:5][C:6]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:9]=[C:8](Cl)[N:7]=1)[CH2:2][CH2:3][CH3:4].C(N(C(C)C)CC)(C)C.[CH2:27]([CH2:29][NH2:30])[OH:28]>CC(N(C)C)=O>[CH2:1]([NH:5][C:6]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:9]=[C:8]([NH:30][CH2:29][CH2:27][OH:28])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 3

HCID 700EthanolamineHCID 81531DiisopropylethylamineHCID 14045984N~2~,N~4~-Dibutyl-6-chloro-1,3,5-triazine-2,4-diamine

Produkt 1

HCID 24012324HCID 24012324, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

In a 500-ml eggplant-shaped flask were placed 77.8 millimoles of N,N′-dibutyl-6-chloro-[1,3,5]triazine-2,4-diamine, 100 ml of dimethylacetamide, 233.5 millimoles of diisopropylethylamine, and 155.6 millimoles of ethanolamine and the mixture was heated at 160° C. with stirring. After 1.5 hours, the mixture was cooled to room temperature and the solvent was distilled off. A white precipitate in the residue was filtered and the filtrate was purified by silica gel column chromatography to give N,N′-dibutyl-N″-hydroxyethyl-[1,3,5]triazine-2,4,6-triamine.

Aufarbeitung

  1. customIn a 500-ml eggplant-shaped flask were placed
  2. distillationthe solvent was distilled off
  3. filtrationA white precipitate in the residue was filtered
  4. customthe filtrate was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-12fdd154564e4bf480d4f2c430987dab
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198387B2

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