Water → 1-Ethyl-3-(2-methoxy-4-nitrophenyl)pyridin-2(1H)-one

HRID 218522Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 218522
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[C:13](=[O:18])[NH:14][CH:15]=[CH:16][CH:17]=1.C(=O)([O-])[O-].[K+].[K+].I[CH2:26][CH3:27].O>CN(C=O)C>[CH2:26]([N:14]1[CH:15]=[CH:16][CH:17]=[C:12]([C:4]2[CH:5]=[CH:6][C:7]([N+:9]([O-:11])=[O:10])=[CH:8][C:3]=2[O:2][CH3:1])[C:13]1=[O:18])[CH3:27]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 595867673-(2-Methoxy-4-nitrophenyl)pyridin-2(1H)-one

Produkt 1

HCID 595867171-Ethyl-3-(2-methoxy-4-nitrophenyl)pyridin-2(1H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

350 mg (1.42 mmol) of the product from example 55A are suspended in 3.5 ml of DMF. To this are added 393 mg (2.84 mmol) of potassium carbonate and 266 mg (1.71 mmol) of iodoethane, and the mixture is left to stir at RT for 3 h. Then it is admixed with water and extracted with dichloromethane. The organic solution is dried over sodium sulfate, concentrated and purified by preparative HPLC. This affords 224 mg (57% of theory) of the title compound.

Aufarbeitung

  1. waitthe mixture is left
  2. extractionextracted with dichloromethane
  3. dry with materialThe organic solution is dried over sodium sulfate
  4. concentrationconcentrated
  5. custompurified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-22deb0e9c8cb406cbc008ac388982d1f
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198267B2

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