Bromine → HCID 178439939, Verbindung

HRID 2186095

Reaktionsgleichung

Reaktionsgleichung von HRID 2186095
[CH:1]([C:4]1[NH:5][C:6]2[CH:12]=[C:11]([NH2:13])[CH:10]=[CH:9][C:7]=2[N:8]=1)([CH3:3])[CH3:2].[Br:14]Br>CC(O)=O>[CH:1]([C:4]1[NH:5][C:6]2[C:12]([Br:14])=[C:11]([NH2:13])[CH:10]=[CH:9][C:7]=2[N:8]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 8207492-Isopropyl-1H-benzo[d]imidazol-5-amine

Produkt 1

HCID 178439939HCID 178439939, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a solution of 0.95 g (5.4 mmol) of 2-isopropyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.19 ml (3.7 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (5% MeOH/EtOAC) to yield 0.89 g (3.5 mmol, 95%) of the desired product.

Aufarbeitung

  1. customresulting
  2. customreaction mixture
  3. customReaction mixture
  4. concentrationwas concentrated in vacuo
  5. custompurified on silica gel column chromatography (5% MeOH/EtOAC)

Quellen und Nachweise

ORD-Eintrag
ord-dc3c363b4cd24f84b4042d9f1270f685
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06403626B1

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