Sodium Cyanide → 3-Benzoylpropionitrile

HRID 2189937

Reaktionsgleichung

Reaktionsgleichung von HRID 2189937
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].C([O-])(=O)C.[K+].[C-:17]#[N:18].[Na+]>C(O)C.O>[O:5]=[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][CH2:2][C:17]#[N:18]

Komponenten

6

Edukt 3

HCID 8929Sodium CyanideHCID 702953-ChloropropiophenoneHCID 517044Potassium Acetate

Produkt 1

HCID 1384653-BenzoylpropionitrileAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 3-chloro-1-phenylpropan-1-one (5.0 g, 29.7 mmol) in hot ethanol (7 mL) was added potassium acetate (2.91 g, 29.77 mmol). After cooling to room temperature, the precipitated salt was removed via filtration. To the filtrate in a septum-sealed flask under a nitrogen bubbler was slowly added sodium cyanide (2.91 g, 59.3 mmol) as a solution in water (10 mL). After stirring at room temperature for 24 hours, ethanol (30 mL) was added, and the mixture was cooled in an ice bath. The precipitate was filtered and rinsed with ethanol to provide the product (3.42 g, 73%) as fluffy white solid.

Aufarbeitung

  1. customthe precipitated salt was removed via filtration
  2. customTo the filtrate in a septum-sealed flask under a nitrogen bubbler was slowly added
  3. temperaturethe mixture was cooled in an ice bath
  4. filtrationThe precipitate was filtered
  5. washrinsed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-2eaa63fff7b54503a240798af339fe52
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324257B2

Verknüpfte Notizen

Wird geladen…