Water → 2-bromo-N-(5-methylpyrazin-2-yl)acetamide

HRID 2192316Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2192316
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[Br:15][CH2:16][C:17](Br)=[O:18].O>CN(C=O)C>[Br:15][CH2:16][C:17]([NH:8][C:5]1[CH:4]=[N:3][C:2]([CH3:1])=[CH:7][N:6]=1)=[O:18]

Komponenten

6

Edukt 4

HCID 962WaterHCID 10796Cesium carbonateHCID 61147Bromoacetyl bromideHCID 3132155-Methylpyrazin-2-amine

Produkt 1

HCID 593162612-bromo-N-(5-methylpyrazin-2-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 5-methyl-pyrazin-2-ylamine and cesium carbonate (11.2 g) dissolved in dry DMF (30 mL) was added by dropwise addition bromoacetylbromide (2.89 g) and the mixture stirred at rt for 2 hours. Water (200 mL) was added and the mixture extracted with ethyl acetate (2×100 mL) and dried over magnesium sulfate. Concentration of the extract to ˜50 mL and addition of isohexane (100 mL) gave the sub-titled compound as a solid (1.64 g).

Aufarbeitung

  1. extractionthe mixture extracted with ethyl acetate (2×100 mL)
  2. dry with materialdried over magnesium sulfate
  3. extractionConcentration of the extract to ˜50 mL and addition of isohexane (100 mL)

Quellen und Nachweise

ORD-Eintrag
ord-054691063b1a44ea94dfbd91cf400a74
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329729B2

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