Phosphorus oxybromide → HCID 58149918, Verbindung

HRID 2192494Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2192494
P(Br)(Br)([Br:3])=O.O=[C:7]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([C:17]#[N:18])[C:11]=2[CH:10]=[CH:9][NH:8]1>ClCCCl>[Br:3][C:7]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([C:17]#[N:18])[C:11]=2[CH:10]=[CH:9][N:8]=1

Komponenten

4

Edukt 2

HCID 24613Phosphorus oxybromideHCID 426091831-Oxo-1,2-dihydroisoquinoline-5-carbonitrile

Produkt 1

HCID 58149918HCID 58149918, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

Phosphorus oxybromide (6.7 g) was added to a suspension of 1-oxo-1,2-dihydro-5-isoquinolinecarbonitrile (2 g) in 1,2-dichloroethane (100 ml). The resulting suspension was heated under reflux overnight. The solvent was removed in vacuo and the residue was washed with aq NaHCO3 (2N, 2×15 ml) to afford, after drying, the title compound (2.27 g). δH (DMSO-d6, 400 MHz): 7.99 (2H, m), 8.54 (3H, m).

Aufarbeitung

  1. temperatureThe resulting suspension was heated
  2. temperatureunder reflux overnight
  3. customThe solvent was removed in vacuo
  4. washthe residue was washed with aq NaHCO3 (2N, 2×15 ml)
  5. customto afford
  6. customafter drying

Quellen und Nachweise

ORD-Eintrag
ord-1af97f074bb74f18af4b25eb8515e0bf
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329730B2

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