Dichloromethane → 6-Ethylpyridin-2-amine

HRID 2197704

Reaktionsgleichung

Reaktionsgleichung von HRID 2197704
C(OC(=O)C(=C[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=1)C(OCC)=O)C.Cl.NO.[OH-].[Na+].[CH2:26](Cl)Cl>CCO.O>[CH2:19]([C:15]1[N:14]=[C:13]([NH2:12])[CH:18]=[CH:17][CH:16]=1)[CH3:26]

Komponenten

7

Edukt 4

HCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 83264Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonateHCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 890216-Ethylpyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

The product from Example 1a (4.93 g, 0.025 mol) was dissolved in a mixture of EtOH (80 mL) and water (30 mL). To this was added hydroxylamine hydrochloride (8.6 g, 0.123 mol) and the resulting mixture heated to 100° C. for 8 h. The reaction mixture was poured into dilute sodium hydroxide solution and the crude product isolated by extraction with CH2Cl2 and dried over MgSO4 filtered and concentrated under vacuum giving the title compound. The material was used as isolated.

Aufarbeitung

  1. dry with materialdried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-1e80fa44fa2048f6874f4c4088eb0c94
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338605B2

Verknüpfte Notizen

Wird geladen…