Isopropylamine → 1-(Iso-propyl)-3-benzyloxyazetidine

HRID 2198856

Reaktionsgleichung

Reaktionsgleichung von HRID 2198856
[CH2:1]([O:8][CH:9]([CH2:12]Br)[CH2:10]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:14]([NH2:17])([CH3:16])[CH3:15]>O>[CH2:1]([O:8][CH:9]1[CH2:12][N:17]([CH:14]([CH3:16])[CH3:15])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 561824(((1,3-Dibromopropan-2-yl)oxy)methyl)benzene

Produkt 1

HCID 205173241-(Iso-propyl)-3-benzyloxyazetidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

11 Parts of 2-benzyloxy-1,3-dibromo-propane, 30 parts of iso-propylamine and 30 parts of water were added to a stainless autoclave, and the mixture was heated at 80° C. for 2 hours with agitation. The reaction mixture was cooled and treated in the same manner as in Example 29, followed by distillation under reduced pressure. As a result, 18 parts of 3-benzyloxy-1-(iso-propyl)azetidine boiling at 104°-107° C. under 2 mm Hg were obtained.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. additiontreated in the same manner as in Example 29
  3. distillationfollowed by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-254474e6da6d4692a5dc96eee36f2060
Quelldatensatz
uspto-grants-1982_11
Patentnummer
US04360464

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