Methanesulfonyl chloride → Methanesulfonic acid 1-(6-{(1R,4S)-4-[3-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-ureido]-1,2,3,4-tetrahydro-naphthalen-1-yloxy}-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-piperidin-4-ylmethyl ester

Reaktionsgleichung

[CH3:1][S:2](Cl)(=[O:4])=[O:3].[C:6]([C:10]1[CH:11]=[C:12]([NH:16][C:17]([NH:19][C@@H:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[C@H:23]([O:30][C:31]3[CH:32]=[CH:33][C:34]4[N:35]([C:37]([N:40]5[CH2:45][CH2:44][CH:43]([CH2:46][OH:47])[CH2:42][CH2:41]5)=[N:38][N:39]=4)[CH:36]=3)[CH2:22][CH2:21]2)=[O:18])[N:13]([CH3:15])[N:14]=1)([CH3:9])([CH3:8])[CH3:7].CCN(C(C)C)C(C)C>C(Cl)Cl>[C:6]([C:10]1[CH:11]=[C:12]([NH:16][C:17](=[O:18])[NH:19][C@@H:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[C@H:23]([O:30][C:31]3[CH:32]=[CH:33][C:34]4[N:35]([C:37]([N:40]5[CH2:45][CH2:44][CH:43]([CH2:46][O:47][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:42][CH2:41]5)=[N:38][N:39]=4)[CH:36]=3)[CH2:22][CH2:21]2)[N:13]([CH3:15])[N:14]=1)([CH3:9])([CH3:7])[CH3:8]