Reaktionsgleichung
[CH:1]1([N:6]2[C:14]3[CH:13]=[CH:12][NH:11][C:10](=[O:15])[C:9]=3[CH:8]=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C[Si](C)(C)N=C(O[Si](C)(C)C)C.C1C(=O)N([Br:35])C(=O)C1.O>CN(C=O)C>[Br:35][C:8]1[C:9]2[C:10](=[O:15])[NH:11][CH:12]=[CH:13][C:14]=2[N:6]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)[CH:7]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
To a solution of 1-cyclopentyl-1,5-dihydro-4H-pyrrolo[3,2-c]pyridin-4-one (3.40 g) in DMF (42.0 mL) was added trimethylsilyl N-(trimethylsilyl)ethanimidate (7.52 g) at room temperature, and the mixture was stirred at 40° C. for 3 hr. The reaction mixture was allowed to be cooled to room temperature, and NBS (3.59 g) was added thereto at room temperature. The reaction mixture was stirred overnight at room temperature, water was added thereto, and the mixture was stirred at room temperature for 2 hr. The white precipitate was collected by filtration, and dried under reduced pressure to give the title compound (3.28 g).
Aufarbeitung
- temperatureto be cooled to room temperature
- customat room temperature
- stirringThe reaction mixture was stirred overnight at room temperature
- stirringthe mixture was stirred at room temperature for 2 hr
- filtrationThe white precipitate was collected by filtration
- customdried under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-f96fa7a44c5d4f9cb7b5f2f9ff9ae4cd
- Quelldatensatz
- uspto-grants-2016_06
- Patentnummer
- US09371320B2
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