Water → Benzyl 2-(1-aminoethyl)morpholine-4-carboxylate

HRID 2206654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2206654
[C:1]([CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:5]1)(=O)[CH3:2].C([O-])(C)=O.[NH4+].[BH3-]C#[N:27].[Na+].O>C1COCC1.CO>[NH2:27][CH:1]([CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:5]1)[CH3:2]

Komponenten

6

Edukt 4

HCID 962WaterHCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 18354411Phenylmethyl 2-acetyl-4-morpholinecarboxylate

Produkt 1

HCID 18354340Benzyl 2-(1-aminoethyl)morpholine-4-carboxylateAusbeute 40 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of benzyl 2-acetylmorpholine-4-carboxylate (5.0 g, 19 mmol) in THF/MeOH (1/5, 100 mL) were added AcONH4 (14.6 g, 190 mmol) and NaBH3CN (11.8 g, 190 mmol). The mixture was stirred at room temperature for 50 hr. The mixture was concentrated to give the crude. Water (20 mL) was added and the mixture was extracted by ethyl acetate (60 mL*3), 1N HCl, was added into the combined organic layers. The aqueous layer was concentrated, brought to above pH>8 with 2N NaOH and extracted by ethyl acetate (60 mL*3). The organic layer was washed with brine, dried over sodium sulfate. The mixture was concentrated to give benzyl 2-(1-aminoethyl)morpholine-4-carboxylate (2.0 g, 40%).

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. customto give the crude
  3. extractionthe mixture was extracted by ethyl acetate (60 mL*3), 1N HCl
  4. additionwas added into the combined organic layers
  5. concentrationThe aqueous layer was concentrated
  6. extractionextracted by ethyl acetate (60 mL*3)
  7. washThe organic layer was washed with brine
  8. dry with materialdried over sodium sulfate
  9. concentrationThe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-a2677daa602e4c4d8d688d47a9b70c7f
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09371331B2

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