Water → tert-Butyl ((1H-benzo[d]imidazol-2-yl)methyl)carbamate

HRID 2213148

Reaktionsgleichung

Reaktionsgleichung von HRID 2213148
O(C)[Na].[C:4]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])#[N:5].Cl.Cl.[C:17]1(N)[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH2:23].O>CO>[NH:5]1[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]=[C:4]1[CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:13])[CH3:12]

Komponenten

6

Edukt 4

HCID 962WaterHCID 119901,2-Phenylenediamine dihydrochlorideHCID 545844tert-butyl N-(cyanomethyl)carbamateHCID 178418582HCID 178418582, Verbindung

Produkt 1

HCID 11448004tert-Butyl ((1H-benzo[d]imidazol-2-yl)methyl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3.32 g of a 30% NaOCH3 solution were added to tert-butyl cyanomethylcarbamate (3 g; 19.21 mmol) in 20 ml of CH3OH, and the mixture was stirred at room temperature for 1 h. After addition of 3.4 g of 1,2-phenylenediamine bishydrochloride, the reaction mixture was stirred further overnight and then added to 100 ml of H2O, and the resulting solid was filtered off and dried in vacuo.

Aufarbeitung

  1. stirringthe reaction mixture was stirred further overnight
  2. filtrationthe resulting solid was filtered off
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-dbbdafbfa47c4854b58d80974b580e8b
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07105508B1

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