Bromine → 5-Bromo-2-hydroxypyridine-3-carbonitrile

HRID 2214739

Reaktionsgleichung

Reaktionsgleichung von HRID 2214739
[Br:1]Br.[O:3]=[C:4]1[C:9]([C:10]#[N:11])=[CH:8][CH:7]=[CH:6][NH:5]1>C(O)(=O)C>[Br:1][C:7]1[CH:8]=[C:9]([C:10]#[N:11])[C:4](=[O:3])[NH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 5775433-Cyano-2-pyridone

Produkt 1

HCID 72048705-Bromo-2-hydroxypyridine-3-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Bromine (29 ml, 560 mmol) was added to a stirred solution of 2-oxo-1,2-dihydro-pyridine-3-carbonitrile (34 g, 280 mmol) in acetic acid (180 ml) at room temperature. After 14 hours the reaction mixture was concentrated in vacuo and the resulting oil was trituated with ethanol to afford the title compound as a solid.

Aufarbeitung

  1. concentrationAfter 14 hours the reaction mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-88e0564d21944360a2cc532a9dc99ba6
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109199B2

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