Triethylamine → HCID 178483833, Verbindung

HRID 2225530

Reaktionsgleichung

Reaktionsgleichung von HRID 2225530
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[F:13])[CH:5]=[CH:6][C:7]([OH:9])=O.P(Cl)(OCC)(OCC)=O.C(N(CC)CC)C.[CH3:30][N:31]([CH3:42])[CH2:32][CH2:33][NH:34][C@H:35]1[CH2:40][CH2:39][C@H:38]([CH3:41])[CH2:37][CH2:36]1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[CH3:30][N:31]([CH3:42])[CH2:32][CH2:33][N:34]([C@H:35]1[CH2:36][CH2:37][C@H:38]([CH3:41])[CH2:39][CH2:40]1)[C:7](=[O:9])[CH:6]=[CH:5][C:4]1[CH:10]=[CH:11][C:12]([F:13])=[C:2]([F:1])[CH:3]=1

Komponenten

7

Edukt 4

HCID 8471TriethylamineHCID 13139Diethyl chlorophosphateHCID 1454863-(3,4-Difluorophenyl)prop-2-enoic acidHCID 178483797HCID 178483797, Verbindung

Produkt 1

HCID 178483833HCID 178483833, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Using 1.1 g of 3,4-difluorocinnamic acid, 1.4 ml of diethyl chlorophosphate, 1.4 ml of triethylamine, 60 ml of methylene chloride, 1.4 ml of N-(2-dimethylaminoethyl)-trans-4-methylcyclohexylamine (Example 78), and 0.25 g of 4-dimethylaminopyridine, a reaction similar to that conducted in Example 81 was carried out. As a result, 1.74 g of N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-3,4-difluorocinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Aufarbeitung

  1. customa reaction similar to

Quellen und Nachweise

ORD-Eintrag
ord-113951c4b7374704bebb44fd9c4485fb
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05344845

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