Water → 4-(3-Bromopropyl)phenol

HRID 2227105Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2227105
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]O)=[CH:4][CH:3]=1.[Br:12]C(Br)(Br)Br.O>ClCCl>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][Br:12])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 11205Carbon tetrabromideHCID 824523-(4-Hydroxyphenyl)propanol

Produkt 1

HCID 148170364-(3-Bromopropyl)phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3-(4-hydroxyphenyl)-1-propanol 3A (4.0 g) and tripohenylphosphine (7.96 g) in anhydrous dichloromethane (77 mL), cooled to 0° C., is added, dropwise, a solution of tetrabromomethane (9.59 g) in anhydrous dichloromethane (15.4 mL). The reaction mixture gradually warmed to room temperature and allowed to stir overnight. The solution is then poured into water and extracted with ethyl acetate. The combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

Aufarbeitung

  1. additionis added
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layers are washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationThe solution is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ddc232abfd544438b4acbac4d5921aaa
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06413448B1

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