3,5-Dichloroaniline → 2-(3,5-Dichlorophenylamino)nicotinic acid
Reaktionsgleichung
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:11][C:12]1[CH:13]=[C:14]([CH:16]=[C:17]([Cl:19])[CH:18]=1)[NH2:15]>C(O)(=O)C>[Cl:11][C:12]1[CH:13]=[C:14]([NH:15][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH:16]=[C:17]([Cl:19])[CH:18]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-Chloronicotinic acid (10 g) was combined with 3,5-dichloroaniline (15 g) in 150 mL acetic acid and heated at reflux for 4 hr. Upon cooling, a white solid formed which was collected by filtration, washed with acetic acid, water, and dried to give 17.6 g of 2-(3,5-dichlorophenylamino)nicotinic acid.
Aufarbeitung
- temperatureheated
- temperatureat reflux for 4 hr
- temperatureUpon cooling
- customa white solid formed which
- filtrationwas collected by filtration
- washwashed with acetic acid, water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-49906059e42f44d1a88a703f71e97cdc
- Quelldatensatz
- uspto-grants-2002_07
- Patentnummer
- US06414153B1
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