Sodium borohydride → Ethyl2-(1,2-dihydro-1-acenaphthylenyl)acetate

HRID 2230265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2230265
[BH4-].[Na+].[CH2:3]([O:5][C:6](=[O:20])[CH:7]=[C:8]1[C:18]2=[C:19]3[C:14](=[CH:15][CH:16]=[CH:17]2)[CH:13]=[CH:12][CH:11]=[C:10]3[CH2:9]1)[CH3:4]>CO.Cl[Pd]Cl>[CH2:3]([O:5][C:6](=[O:20])[CH2:7][CH:8]1[C:18]2=[C:19]3[C:14](=[CH:15][CH:16]=[CH:17]2)[CH:13]=[CH:12][CH:11]=[C:10]3[CH2:9]1)[CH3:4]

Komponenten

5

Edukt 2

HCID 4311764Sodium borohydrideHCID 70179131Ethyl2-(1,2-dihydro-1-acenaphthylenylidene)acetate

Produkt 1

HCID 13715672Ethyl2-(1,2-dihydro-1-acenaphthylenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24290Palladium ChlorideKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

55 mg of PdCl2 in 5 ml of methanol are treated with 25 mg of sodium borohydride. After 15 minutes' stirring, the compound obtained in Step B (1 g, 4.20.10−3 mol), diluted with methanol (25 ml), is added. The mixture is purged with argon and placed under a hydrogen atmosphere. After 2 hours 30 minutes' hydrogenation, the reaction mixture is filtered over Celite, rinsed and then evaporated under reduced pressure.

Aufarbeitung

  1. additionis added
  2. customThe mixture is purged with argon
  3. waitAfter 2 hours 30 minutes' hydrogenation
  4. filtrationthe reaction mixture is filtered over Celite
  5. washrinsed
  6. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-455c973d4abd4c9dbc62bc0345c0c13c
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06423870B1

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