Benzyl Alcohol → Benzyl 2-bromopropanoate

HRID 223420

Reaktionsgleichung

Reaktionsgleichung von HRID 223420
[Br:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[CH2:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O>C(OCC)C>[Br:1][CH:2]([CH3:6])[C:3]([O:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4]

Komponenten

5

Edukt 3

HCID 244Benzyl AlcoholHCID 962WaterHCID 979802-Bromopropanoyl chloride

Produkt 1

HCID 298874Benzyl 2-bromopropanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

2-Bromopropionyl chloride (213.4 g) was added dropwise to benzyl alcohol (145.8 g) with stirring under a stream of nitrogen, keeping the temperature of the reaction mixture below 30° C. by cooling with cold water. When all the acid chloride has been added, the mixture was stirred for another two hours at ambient temperature. The reaction mixture was then diluted with diethyl ether (200 ml) and washed with water until free of acid. The ethereal solution was dried and evaporated and the residue distilled to give benzyl 2-bromopropionate, b.p. 82°-85°/0.5 Torr.

Aufarbeitung

  1. customthe temperature of the reaction mixture below 30° C.
  2. stirringthe mixture was stirred for another two hours at ambient temperature
  3. washwashed with water until free of acid
  4. customThe ethereal solution was dried
  5. customevaporated
  6. distillationthe residue distilled

Quellen und Nachweise

ORD-Eintrag
ord-1c00f06cea1740ed92e24c97ab00991d
Quelldatensatz
uspto-grants-1982_10
Patentnummer
US04354034

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